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J Knee Surg. 2019 Feb 1. doi: 10.1055/s-0038-1676770. [Epub ahead of print]

A New Total Knee Arthroplasty Design Has Significantly Better Early Implant Survivorship than a Previous Gold-Standard Design-A Retrospective Analysis of 1,000 Cases.

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Nottingham Elective Orthopaedic Services, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, United Kingdom.


This study examined whether a new total knee arthroplasty (TKA) prosthesis improved implant survivorship and reoperation rates compared with a gold-standard, established TKA. A retrospective analysis of the first 500 consecutive new TKAs was compared with a consecutive series of the last 500 currently available TKAs performed by a single senior surgeon in one center. The primary outcome measure was revision of the femoral, tibial, or patellar component. A secondary outcome was reoperation for any reason. The new-TKA group had a significantly reduced revision rate at up to 5 years follow-up (p = 0.02). Reoperation rates for any reason were similar (p = 0.3). The new TKA design has a significantly better early revision rate compared with a currently available gold-standard TKA. This is the largest study of 1,000 cases comparing a new TKA design with a currently available design with excellent midterm results. It demonstrates very favorable early clinical results for the new TKA design, providing reassurance for patients, surgeons, and regulatory bodies.


Conflict of interest statement

Peter James is a designer of the new TKA and thus receives royalties from DePuy Synthes. He is also a consultant to DePuy Synthes. Nottingham Elective Orthopaedic Services receives fellowship funding and support from DePuy Synthes, ZimmerBiomet, Wright Medical and Exactech.

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