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Mult Scler Relat Disord. 2019 Apr;29:108-110. doi: 10.1016/j.msard.2019.01.035. Epub 2019 Jan 23.

Bilateral cingulate cortices lesions in two autoantibodies directed against MOG (MOG-Ab)-positive patients.

Author information

1
Department of Neurology, Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
2
Department of Neurology, Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. Electronic address: shiroh46@med.kurume-u.ac.jp.
3
Department of Radiology, Kurume University School of Medicine, Japan.
4
Department of Neurology, Tohoku University Graduate School of Medicine, Japan; Department of Neurology, National Hospital Organization Yonezawa Hospital, Japan.

Abstract

There are no specific radiologic features in MOG-Ab (autoantibodies directed against myelin oligodendrocyte glycoprotein)-associated diseases. We present two MOG-Ab-positive patients with symmetrical lesions in the bilateral cingulate cortex of the frontal and parietal lobes. Those lesions showed hyperperfusion in acute phase and hypoperfusion in chronic phase on brain SPECT. In both patients, steroid therapy was effective in acute phase and for prevention of recurrence. High signal in the bilateral cingulate cortex on MR T2-weighted and FLAIR images might to be one of the unique findings considered MOG-Ab associated diseases.

KEYWORDS:

Cingulate cortex; MRI; Myelin oligodendrocyte glycoprotein (MOG); SPECT; Treatment

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