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Int J Biol Macromol. 2019 May 1;128:804-813. doi: 10.1016/j.ijbiomac.2019.01.193. Epub 2019 Jan 30.

Therapeutic effect and mechanism of polysaccharide from Alpiniae oxyphyllae fructus on urinary incontinence.

Author information

1
School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai, Shangdong 264003, PR China; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, PR China. Electronic address: hykh888@163.com.
2
Shandong College of Traditional Chinese Medicine, Yantai, Shangdong 264199, PR China.
3
Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, PR China.
4
Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223001, Jiangsu, PR China. Electronic address: lihailun101@sina.com.

Abstract

The purpose of this paper was to investigate the effects and mechanism of polysaccharide (PAOF) from Alpiniae oxyphyllae fructus on urinary incontinence (UI) in old-age hydruric model rats (OHMR). Results suggested that PAOF can significantly reduce the urination volume, Na+, Cl- emission and increase K+ excretion of OHMR. In addition, PAOF can increase the content of aldosterone (ALD) and antidiuretic hormone (ADH) in blood of OHMR. The coefficients of spleen, thymus and adrenal of OHMR were improved by PAOF. Furthermore, PAOF can not only elevate significantly the expression of β3-adrenoceptor mRNA in bladder detrusor of OHMR, but also increase the content of adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) in bladder detrusor of OHMR. Meanwhile, PAOF can elevate significantly the expression of PKA protein in bladder detrusor of rats with polyuria. The data implied that PAOF may offer therapeutic potential against UI.

KEYWORDS:

Polysaccharide from Alpiniae oxyphyllae fructus; Therapeutic effects and mechanism; Urinary incontinence of aging rats

PMID:
30708017
DOI:
10.1016/j.ijbiomac.2019.01.193
[Indexed for MEDLINE]

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