Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma

Curr Eye Res. 2019 Jun;44(6):619-622. doi: 10.1080/02713683.2019.1578378. Epub 2019 Feb 18.

Abstract

Purpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls. Patients and Methods: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry. Results: A significant increase in aqueous humor SDMA level was detected in POAG patients compared with controls (p = 0.0115). No significant difference was detected in plasma and aqueous humor ADMA, L-Arg levels. Conclusion: The aqueous humor levels of SDMA are found to be associated with POAG. The result of this current study supports the role of nitric oxide pathway in glaucoma.

Keywords: Glaucoma; L-arginine; asymmetric dimethylarginine; symmetric dimethylarginine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aqueous Humor / metabolism*
  • Arginine / analogs & derivatives*
  • Arginine / blood
  • Arginine / metabolism
  • Case-Control Studies
  • Chromatography, High Pressure Liquid
  • Female
  • Glaucoma, Open-Angle / metabolism*
  • Humans
  • Intraocular Pressure / physiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Tandem Mass Spectrometry
  • Tonometry, Ocular

Substances

  • symmetric dimethylarginine
  • Arginine