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Curr Neurovasc Res. 2019 Jan 31. doi: 10.2174/1567202616666190131162811. [Epub ahead of print]

Current medical and surgical stroke prevention therapies for patients with carotid artery stenosis.

Author information

1
Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo. Norway.
2
Department of Cardiothoracic Surgery, Oslo University Hospital, Rikshospitalet, Oslo. Norway.

Abstract

Carotid artery stenosis (CAS) is a marker of systemic atherosclerosis and patients with CAS are at high risk of vascular events in multiple vascular locations, including ipsilateral ischemic stroke. Both medical and surgical therapies have been demonstrated effective in reducing this risk. The optimal management for patients with asymptomatic carotid artery stenosis remains controversial. In patients with symptomatic CAS ≥70%, CEA has been demonstrated to reduce the risk of stroke. With risk of recurrent stroke being particularly high in the first 2 weeks after first event, CEA or carotid angioplasty with stenting provides maximal benefits to patients with symptomatic CAS ≥70% if performed within this «2-week» target. Several large ongoing trials are currently comparing the risks and benefits of carotid revascularization versus medical therapy alone.

KEYWORDS:

Carotid artery stenosis; cardiovascular risk; carotid endarterectomy; carotid stenting; clinical trials; prevention; stroke

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