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Br J Ophthalmol. 2019 Apr;103(4):573-576. doi: 10.1136/bjophthalmol-2018-313263. Epub 2019 Jan 31.

Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population.

Author information

1
Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
2
Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
3
Department of Medicine, Physician-Scientist Program, Yonsei University Graduate School of Medicine, Seoul, Korea.
4
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
5
Department of Ophthalmology, Chonnam National University, Gwangju, Korea.
6
Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
7
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
8
Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea mueta@koto.kpu-m.ac.jp seoky@yuhs.ac.
9
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan mueta@koto.kpu-m.ac.jp seoky@yuhs.ac.

Abstract

BACKGROUND/AIMS:

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population.

METHODS:

This multicentre case-control study enrolled 40 Korean patients with CM-SJS/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes. RESULTS : The carrier frequency and gene frequency of HLA-A*02:06 were 37.5 % and 20.0 %, respectively, in patients, and 16.7 % and 9.6 %, respectively, in controls (p=0.018). The carrier frequency of HLA-C*03:04 was 30 % in patients and 10.8 % in controls, and gene frequency of HLA-C*03:04 was 15 % in patients and 5.4 % in controls (p=0.003). The carrier frequency and gene frequency of HLA-C*03:03 were 2.5 % and 1.3 %, respectively, in patients, and 20 % and 10.4 %, respectively, in controls (p=0.006). CONCLUSIONS : As per our results, we suggest that HLA-A*02:06 and HLA-C*03:04 might be positive markers for CM-SJS/TEN with SOC, and HLA-C*03:03 might be an indicator of protection against CM-SJS/TEN with SOC in the Korean population.

KEYWORDS:

experimental &#8211 laboratory; genetics; ocular surface

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