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J Craniomaxillofac Surg. 2019 Mar;47(3):500-504. doi: 10.1016/j.jcms.2019.01.006. Epub 2019 Jan 11.

Salivary malignancies- medical, demographic and diagnostic analysis.

Author information

1
Department of Oral and Maxillofacial Surgery, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel; Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel.
2
Department of Nuclear Medicine Rambam Medical Center, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel; Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel.
3
Department of Oral and Maxillofacial Surgery, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel; Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa 31096, Israel. Electronic address: nagler@tx.technion.ac.il.

Abstract

We examined systemic medical and demographic characteristics of patients diagnosed with salivary malignant tumors in order to better understand the pathogenesis of the disease. Of 101 patients who received definitive treatment for malignant salivary gland tumors in our medical center, 22 died with disease (DwD) and were compared with the remaining 79 patients (Other). Mean ages were 66.7 years (median 68.0) in DwD group and 58.7 years (median 59.0) in the Others. The difference is significant (p = 0.037). Mucoepidermoid carcinoma was the diagnosis in 27.3% of DwDs and 27.8% of the others, Adenoidcystic carcinoma in 36.4% vs 21.5%, SCC and Acinic cell carcinoma were diagnosed in 18.3% vs 7.6% and 4.6% vs 7.6%, respectively. Alcohol consumption, concomitant malignancies, and chronic illnesses other than hypertension, were similar in the two groups, but hypertension (63.6%) in the DwD group was significantly higher than in the Other group (26.6%), (p = 0.0010). Smoking was also significantly different between the two groups: 50% of the DwD vs. 27.9% of the Others group smoked cigarettes. Similar distribution of the various malignant tumors in both groups emphasizes the relative importance of systemic factors such as smoking, aging and hypertension, in the salivary carcinogenesis process.

KEYWORDS:

Demographic; Diagnosis; Medical; Salivary malignancies

PMID:
30704804
DOI:
10.1016/j.jcms.2019.01.006

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