Format

Send to

Choose Destination
Org Biomol Chem. 2019 Feb 20;17(8):2153-2161. doi: 10.1039/c8ob03102a.

A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans.

Author information

1
College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, Republic of Korea. kaylee@dongguk.edu.

Abstract

2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.

PMID:
30702732
DOI:
10.1039/c8ob03102a

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center