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Medicine (Baltimore). 2019 Feb;98(5):e14076. doi: 10.1097/MD.0000000000014076.

Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma.

Author information

1
Department of Gynecology and Obstetrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Abstract

To explore the role of hScrib in the pathogenesis of endometriosis.This was a retrospective study of 240 women in our hospital between January 2014 and January 2017. The expression of hScrib in endometrium (EM), endometriosis (EMs), and endometrial adenocarcinoma (EC) was investigated, and compared the differences among them. Serum levels, protein expressions, localizations, and correlations of hScrib and E-cadherin were determined.The levels of serum soluble hScrib and E-cadherin were significantly highest in EC, followed by EMs, and healthy women (P < .05). hScrib protein content was opposite result in 3 tissues (P < .05), and was negatively correlated with r-AFS stage in EMs. The location changed from membrane to cytoplasm. Co-localization of hScrib with E-cadherin was found at extensive cell-cell boundaries in EMs.hScrib and E-cadherin may be as new diagnostic markers of endometriosis. Low expression of hScrib leads to the loss of cell polarity and stability. Also, hScrib may induce EMT through regulating E-cadherin, might play an important role in pathogenesis of endometriosis.

PMID:
30702562
PMCID:
PMC6380690
DOI:
10.1097/MD.0000000000014076
[Indexed for MEDLINE]
Free PMC Article

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