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Mol Nutr Food Res. 2019 Apr;63(7):e1800990. doi: 10.1002/mnfr.201800990. Epub 2019 Feb 11.

Serum Omega-6 Fatty Acids and Immunology-Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross-Sectional Analysis in Healthy Children.

Author information

1
Department of Nutrition, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
2
The Lipid Clinic, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.
3
Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
4
Faculty of Medicine, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
5
Department of Obstetrics, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.
6
Section of Specialized Endocrinology, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.
7
Research Institute of Internal Medicine, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
8
Institute of Clinical Medicine, P.O. Box 1171 Blindern, 0318, Oslo, Norway.
9
K.G. Jebsen Inflammatory Research Center, P.O. Box 1171 Blindern, 0318, Oslo, Norway.
10
Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.
11
Norwegian National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.

Abstract

SCOPE:

Some studies suggest that a high dietary intake of omega-6 fatty acids is pro-inflammatory. However, whether omega-6 fatty acids actually cause pathogenic inflammation in humans is debated. Therefore, the associations between expression of immunology-related genes in peripheral blood mononuclear cells (PBMCs) and serum total omega-6 PUFA status are investigated.

METHODS AND RESULTS:

Serum fatty acid profile and expression of 460 immunology-related genes in PBMCs from 58 healthy children (6-13 years) is measured, and examined the expression differences between children with high or low total omega-6 PUFA status (upper vs lower tertile). Taken together, both univariate analyses and integrated omics analyses support that while high omega-6 PUFA level associated with higher expressing of genes related to innate immune responses, it also associated with lower expression of several genes related to adaptive immune responses.

CONCLUSION:

Omega-6 PUFA status associated both positively and negatively with expression of specific immunology-related genes in PBMCs in healthy children. The results may suggest a nuanced role for omega-6 fatty acids in the interphase of lipids and inflammation, and warrants further examination in gene-environment studies and randomized controlled trials.

KEYWORDS:

children; gene expression; inflammation; nanostring; omega-6

PMID:
30702198
DOI:
10.1002/mnfr.201800990

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