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Ter Arkh. 2018 Feb 15;90(2):35-42. doi: 10.26442/terarkh201890235-42.

European Registry on the management of Helicobacter pylori infection (Hp-EuReg): analysis of 2360 patients receiving first-line therapy in Russia.

Author information

1
A.S. Loginov Moscow clinical scientific practical center of Moscow Healthcare Department , Moscow, Russia.
2
Tver state medical University, Ministry of health of Russia, Tver, Russia.
3
Gastrocenter, Perm, Russia.
4
SM-clinic, St. Petersburg, Russia.
5
South Ural state medical University, Ministry of Health of Russia, Chelyabinsk, Russia.
6
Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia.
7
The First clinical medical center, Kovrov, Russia.
8
Kazan state medical University, Ministry of Health of Russia, Kazan, Russia.
9
Novosibirsk state medical University, Ministry of Health of Russia, Novosibirsk, Russia.
10
Omsk state medical University, Ministry of health of Russia, Omsk, Russia.
11
Krasnoyarsk scientific center of the Siberian branch of the Russian Academy of Sciences, separat of division "Scientific research Institute of medical problems of the North", Krasnoyarsk, Russia.
12
Polyclinic №3 of Department for presidential Affairs of the Russian Federation, Moscow, Russia.
13
I.I. Mechnikov North-Western state medical University, Ministry health of Russia, St. Petersburg, Russia.
14
Smolensk state medical University Ministry of health of Russia, Smolensk, Russia.
15
Republican gastroenterology center, "Republican clinical hospital", Ministry of health of Chuvash Republic, I.N. Ulyanov state University, Cheboksary, Russia.
16
Kemerovo state medical University, Ministry health of Russia, Kemerovo, Russia.
17
A.I. Evdokimov Moscow state medical dental University, Ministry of Health of Russia, Moscow, Russi.
18
Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, St. Petersburg, Russia.
19
I.P. Pavlov Ryazan State Medical University, Ministry of health of Russia, Ryazan, Russia.
20
V. I. Razumovsky Saratov state medical University, Ministry of health of Russia, Saratov, Russia.
21
I.P. Pavlov Ryazan State Medical University, Ministry of health of Russia, Ryazan, Russi.
22
St. Petersburg state University, St. Petersburg, Russia.
23
Kazan (Volga region) Federal University, Kazan, Russia.
24
Laboratoire of Bacteriology, Hospital Pellegrin, Bordeaux, France.
25
Department of Gastroenterology, Tallaght Hospital/Trinity College Dublin, Dublin, Ireland.
26
Gastroenterology Unit, University Hospital «Princess», the Institute of Research in Health "Princess" (IIS-IP), Biomedical Research Centre Network of Hepatic and Digestive Diseases (CIBERehd), and Autonomous University of Madrid (UAM), Madrid, Spain.

Abstract

AIM:

European Registry on the management of Helicobacter pylori infection («Hp-EuReg») - a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group, conducted in 27 European countries in order to evaluate the real clinical practice of diagnosis and treatment of H. pylori and its comparison with international recommendations.

MATERIALS AND METHODS:

The analysis of 2360 patients entered in the register by the Russian centres of «Hp-EuReg» in 2013-2017, who were underwent 1st line eradication therapy.

RESULTS:

The most common methods of primary diagnosis of H. pylori are histological (37.7%), rapid urease test (29.2%) and serology (29.7%). The duration of eradication therapy in 9.4% of cases was 7 days, in 65.3% - 10 days, and in 25.3% - 14 days. To control the effec- tiveness of treatment, H. pylori antigen in feces (31.3%), urea breath test (23.4%) and histological method (23.3%) were used. In 3.6% cases was used serology by mistake. In 17.3% of patients control was not carried out. The effectiveness of triple therapy with a PPI, amoxicillin, clar- ithromycin (per protocol) was 67.6%, with 7-day course, 81.1% at 10-day and 86.7% at 14-day course. Eradication rate of triple therapy with addition of bismuth (per protocol) reached 90,6% in the group receiving 10-day scheme and 93.6% in the group receiving the 14-day treatment.

CONCLUSION:

Significant deviations of clinical practice from expert recommendations, most pronounced at the stage of monitoring the effectiveness of therapy, were noted. The suboptimal efficacy of triple therapy is shown.

KEYWORDS:

Helicobacter pylori; Hp-EuReg; eradication therapy; register

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