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BMC Cancer. 2019 Jan 30;19(1):109. doi: 10.1186/s12885-019-5315-z.

Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia.

Xue Y1,2, Ge Y3, Kang M1,2, Wu C4, Wang Y1,2, Rong L1,2, Fang Y5,6.

Author information

1
Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
2
Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.
3
Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
4
Engineering Research Center of Wideband Wireless Communication Technology, Ministry of Education, Nanjing University of Posts and Telecommunications, Nanjing, China.
5
Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China. fyjpaper@163.com.
6
Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China. fyjpaper@163.com.

Abstract

BACKGROUND:

MiRNAs that are potential biomarkers for predicting prognosis for acute myeloid leukemia (AML) have been identified. However, comprehensive analyses investigating the association between miRNA expression profiles and AML survival remain relatively deficient.

METHOD:

In the present study, we performed multivariate Cox's analysis and principal component analysis (PCA) using data from The Cancer Genome Atlas (TCGA) to identify potential molecular signatures for predicting non-M3 AML prognosis.

RESULT:

We found that patients who were still living were significantly younger at diagnosis than those who had died (P = 0.001). In addition, there was a marked difference in living status among different risk category groups (P = 0.022). A multivariate Cox model suggested that three miRNAs were potential biomarkers of non-M3 AML prognosis, including miR-181a-2, miR-25 and miR-362. Subsequently, PCA analyses were conducted to comprehensively represent the expression levels of these three miRNAs in each patient with a PCA value. According to the log-rank test, AML outcome for patients with lower PCA values was significantly different from those with higher PCA values (P < 0.001). Further bioinformatic analysis revealed the biological functions of the selected miRNAs.

CONCLUSION:

We conducted a comprehensive analysis of TCGA non-M3 AML data, identifying three miRNAs that are significantly correlated with AML survival. PCA values for the identified miRNAs are valuable for predicting AML prognosis.

KEYWORDS:

Acute myeloid leukemia; Prognosis; TCGA data; miRNAs

PMID:
30700251
DOI:
10.1186/s12885-019-5315-z
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