Format

Send to

Choose Destination
Nutrients. 2019 Jan 29;11(2). pii: E290. doi: 10.3390/nu11020290.

Blueberries Improve Pain, Gait Performance, and Inflammation in Individuals with Symptomatic Knee Osteoarthritis.

Author information

1
Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. cdu@twu.edu.
2
Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. asmith60@twu.edu.
3
School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX 76204, USA. mavalos1@twu.edu.
4
Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. ssouth@twu.edu.
5
Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. kcrabtree@twu.edu.
6
Center for Research Design and Analysis, Texas Woman's University, Houston, TX 77030, USA. WWang@twu.edu.
7
School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX 76204, USA. YKwon@twu.edu.
8
Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. pvijayagopal@twu.edu.
9
Department of Nutrition and Food Science, Texas Woman's University, Denton, TX 76204, USA. sjuma@twu.edu.

Abstract

Osteoarthritis (OA) is the most common joint disorder in the world and is the most frequent cause of walking related disability among older adults in the US, which brings a significant economic burden and reduces quality of life. The initiation and development of OA typically involves degeneration or progressive loss of the structure and function of articular cartilage. Inflammation is one of the major drives of the progression of OA. Dietary polyphenols have been studied for their anti-inflammatory properties and potential anabolic effects on the cartilage cells. Blueberries are widely consumed and are high in dietary polyphenols, therefore regular consumption of blueberries may help improve OA. The purpose of the present study was to examine the effect of freeze dried whole blueberries on pain, gait performance, and inflammation in individuals with symptomatic knee OA. In a randomized, double-blind trial, adults age 45 to 79 with symptomatic knee OA, were randomized to either consume 40 g freeze-dried blueberry powder (n = 33) or placebo powder (n = 30) daily for four months. Blood draws and assessment of pain and gait were conducted at baseline, two months, and four months. Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaires were used to assess pain and GAITRite® electronic walkway was used to evaluate gait spatiotemporal parameters. WOMAC total score and sub-groups, including pain, stiffness, and difficulty to perform daily activities decreased significantly in the blueberry treatment group (p < 0.05), but improvement of WOMAC total score and difficulty to perform daily activities were not observed in the placebo group. Normal walking pace single support percentage for both limbs increased (p = or < 0.007), while double support percentage for both limbs decreased in the blueberry treatment group (p = or < 0.003). No significant changes were observed in plasma concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, IL-13, matrix metalloproteinases (MMP)-3, MMP-13, and monocyte chemoattractant protein-1 (MCP-1) in both treatment groups. However, an increasing trend for IL-13 concentration and a decreasing trend in MCP-1 concentration were noted in the blueberry group. The findings of this study suggest that daily incorporation of whole blueberries may reduce pain, stiffness, and difficulty to perform daily activities, while improving gait performance, and would therefore improve quality of life in individuals with symptomatic knee OA.

KEYWORDS:

blueberry; gait; inflammation; knee osteoarthritis; pain; polyphenols

PMID:
30699971
PMCID:
PMC6413191
DOI:
10.3390/nu11020290
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center