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PLoS Biol. 2019 Jan 30;17(1):e3000111. doi: 10.1371/journal.pbio.3000111. eCollection 2019 Jan.

Network hubs affect evolvability.

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CMPG Laboratory of Genetics and Genomics, Departement Microbiële en Moleculaire Systemen (M2S), KU Leuven, Leuven, Belgium.
VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, Belgium.
CMPG Laboratory of Predictive Genetics and Multicellular Systems, Departement Microbiële en Moleculaire Systemen (M2S), KU Leuven, Leuven, Belgium.


The regulatory processes in cells are typically organized into complex genetic networks. However, it is still unclear how this network structure modulates the evolution of cellular regulation. One would expect that mutations in central and highly connected modules of a network (so-called hubs) would often result in a breakdown and therefore be an evolutionary dead end. However, a new study by Koubkova-Yu and colleagues finds that in some circumstances, altering a hub can offer a quick evolutionary advantage. Specifically, changes in a hub can induce significant phenotypic changes that allow organisms to move away from a local fitness peak, whereas the fitness defects caused by the perturbed hub can be mitigated by mutations in its interaction partners. Together, the results demonstrate how network architecture shapes and facilitates evolutionary adaptation.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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