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J Infect Dis. 2019 Jun 5;220(1):73-77. doi: 10.1093/infdis/jiz051.

CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes.

Author information

1
Center for AIDS Research, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland.
2
Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland.
3
Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland.
4
Division of Medical Laboratory Sciences, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, Ohio.
5
Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland.

Abstract

Circulating CD8+ T cells and monocytes are activated during human immunodeficiency virus (HIV) infection and colocalize in the aortas of simian immunodeficiency virus-infected nonhuman primates. We hypothesized that CD8+ T cells could exert a proatherosclerotic effect via paracrine actions on monocytes. We found that T-cell receptor-stimulated CD8+ T cells induce monocytes to express tissue factor, a potent activator of coagulation. Tumor necrosis factor was both necessary and sufficient for this effect.

KEYWORDS:

CD8+ T cells; HIV; TNF; cardiovascular disease; monocytes; tissue factor

PMID:
30698729
PMCID:
PMC6548895
[Available on 2020-06-05]
DOI:
10.1093/infdis/jiz051

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