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CJEM. 2019 Jan 30:1-8. doi: 10.1017/cem.2018.500. [Epub ahead of print]

Does the addition of dextrose to IV crystalloid therapy provide clinical benefit in acute dehydration? A systematic review and meta-analysis.

Author information

1
*Department of Pediatrics,Indiana University School of Medicine,Indianapolis, IN.
2
‡Ruth Lilly Medical Library,Indiana University School of Medicine,Indianapolis, IN.
3
†Department of Emergency Medicine,Indiana University School of Medicine,Indianapolis, IN.

Abstract

CLINICIAN'S CAPSULEWhat is known about the topic?Intravenous dextrose halts endogenous ketone production and is commonly recommended in dehydrated patients unable to tolerate oral intake.What did this study ask?Is there evidence that the addition of dextrose to intravenous fluids provides a clinically meaningful benefit in dehydrated patients?What did this study find?Intravenous dextrose has not been shown to provide any important benefit to patients in this setting, but further research is needed.Why does this study matter to clinicians?In dehydrated patients, clinicians should not feel obligated towards dextrose containing solutions, which may be more expensive and less readily available.

KEYWORDS:

dehydration; dextrose; intravenous fluids

PMID:
30698123
DOI:
10.1017/cem.2018.500

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