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Dev Cell. 2019 Jan 28;48(2):131-132. doi: 10.1016/j.devcel.2019.01.013.

SUFU: The Jekyll and Hyde of the Cerebellum.

Author information

1
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA 92037, USA; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
2
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA 92037, USA.
3
Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA 92037, USA. Electronic address: drjeremyrich@gmail.com.

Abstract

Pediatric tumors have enriched the understanding of germline genotype contribution to tumorigenesis. In this issue of Developmental Cell, Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alterations, painting more nuanced roles for SUFU in tumorigenesis and maintenance of Gli2 transcription factor circuitries.

PMID:
30695694
DOI:
10.1016/j.devcel.2019.01.013
[Indexed for MEDLINE]

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