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J Surg Res. 2019 Apr;236:153-158. doi: 10.1016/j.jss.2018.11.044. Epub 2018 Dec 17.

Intestinal Electrical Stimulation to Increase the Rate of Peristalsis.

Author information

1
Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
2
Niche Biomedical LLC, Los Angeles, California.
3
Department of Bioengineering, University of California Los Angeles, Los Angeles, California.
4
Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Department of Bioengineering, University of California Los Angeles, Los Angeles, California; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California; Department of Bioengineering, Stanford University, Stanford, California. Electronic address: jdunn2@stanford.edu.

Abstract

BACKGROUND:

Pediatric gastrointestinal motility disorders are a large and broad group. Some of these disorders have been effectively treated with electrical stimulation. The goal of our present study is to determine whether the rate of intestinal peristalsis can be increased with electrical stimulation.

METHODS:

Juvenile mini-Yucatan pigs were placed under general anesthesia and a short segment of the jejunum was transected. Ultrasound gel was placed inside the segment. The segment of the jejunum was first monitored for 20 min under no stimulation, followed by direct electrical stimulation using a planar electrode. The gel extruded out of the intestine via peristalsis was collected and weighed for each 20-min time interval.

RESULTS:

Effective delivery of the current to the intestine was confirmed via direct measurements. When there was no direct intestinal electrical stimulation, an average of 0.40 g of gel was expelled in 20 min, compared to 1.57 g of gel expelled during direct electrical stimulation (P < 0.01).

CONCLUSIONS:

Direct intestinal electrical stimulation accelerates the transit of gastrointestinal contents. This approach may be useful in the treatment of a range of pediatric motility disorders.

KEYWORDS:

Electrical stimulation; Gastrointestinal motility disorder; Intestine; Peristalsis

PMID:
30694750
DOI:
10.1016/j.jss.2018.11.044

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