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JAMA. 2019 Jan 29;321(4):394-398. doi: 10.1001/jama.2018.21367.

Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: US Preventive Services Task Force Reaffirmation Recommendation Statement.

Author information

1
University of Iowa, Iowa City.
2
Fairfax Family Practice Residency, Fairfax, Virginia.
3
Virginia Commonwealth University, Richmond.
4
Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
5
Stanford University, Stanford, California.
6
Harvard Medical School, Boston, Massachusetts.
7
Oregon Health & Science University, Portland.
8
Columbia University, New York, New York.
9
University of Pennsylvania, Philadelphia.
10
Virginia Tech Carilion School of Medicine, Roanoke.
11
Nationwide Children's Hospital, Columbus, Ohio.
12
Temple University, Philadelphia, Pennsylvania.
13
University of Alabama at Birmingham.
14
University of California, Los Angeles.
15
Boston University, Boston, Massachusetts.
16
Northwestern University, Evanston, Illinois.
17
University of Hawaii, Honolulu.
18
Pacific Health Research and Education Institute, Honolulu, Hawaii.
19
Tufts University, Medford, Massachusetts.

Abstract

Importance:

In the United States, the rate of gonococcal ophthalmia neonatorum was an estimated 0.4 cases per 100 000 live births per year from 2013 to 2017. Gonococcal ophthalmia neonatorum can cause corneal scarring, ocular perforation, and blindness as early as 24 hours after birth. In the absence of ocular prophylaxis, transmission rates of gonococcal infection from mother to newborn are 30% to 50%.

Objective:

To reaffirm the US Preventive Services Task Force (USPSTF) 2011 recommendation on ocular prophylaxis for gonococcal ophthalmia neonatorum.

Evidence Review:

The USPSTF commissioned a reaffirmation evidence update to identify new and substantial evidence sufficient enough to change its prior recommendation.

Findings:

Using a reaffirmation process, the USPSTF found no new data that would change its previous conclusion that topical ocular prophylaxis is effective in preventing gonococcal ophthalmia neonatorum and related ocular conditions. The USPSTF found no new data that would change its previous conclusion that there is convincing evidence that topical ocular prophylaxis of all newborns is not associated with serious harms. Therefore, the USPSTF reaffirms its previous conclusion that there is convincing evidence that topical ocular prophylaxis for all newborns provides substantial benefit.

Conclusions and Recommendation:

The USPSTF recommends prophylactic ocular topical medication for all newborns to prevent gonococcal ophthalmia neonatorum. (A recommendation).

Summary for patients in

PMID:
30694327
DOI:
10.1001/jama.2018.21367
[Indexed for MEDLINE]

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