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Ann Maxillofac Surg. 2018 Jul-Dec;8(2):303-306. doi: 10.4103/ams.ams_41_18.

Distraction Osteogenesis After Stem Cell Transplantation: A Pioneer Approach.

Author information

1
Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
2
Department of Pediatric Hematology, Oncology, Hemostaseology, University Hospital Leipzig, Leipzig, Germany.
3
Department of Orthodontics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
4
Institute of Pathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is an established therapy and is without alternative for certain groups of patients. Successful HSCT induces both long-lasting remission and tolerance without the need for further immunosuppression. In this case, cellular repair and regenerative processes work in a physiologic manner allowing elective surgical procedures, such as the interdisciplinary correction of dentofacial anomalies. Here, we report the successful management of transverse maxillary deficiency by transpalatal distraction and subsequent orthodontic treatment in a 12-year-old boy who underwent HSCT for high-risk acute lymphoblastic leukemia at 5 years of age.

KEYWORDS:

Dentofacial anomaly; stem cell transplantation; transpalatal distraction; transverse maxillary deficiency

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