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J Midlife Health. 2018 Oct-Dec;9(4):210-211. doi: 10.4103/jmh.JMH_79_18.

Malignant Mixed Mullerian Tumor Secondary to Tamoxifen for Ca Breast: Shadow of the Past!

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Department of Obstetrics and Gynaecology, S. P. Medical College, Bikaner, Rajasthan, India.
Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur, Rajasthan, India.


Tamoxifen is used in the treatment of hormone-responsive breast cancer because of its antiestrogenic effect. However, it also has an estrogenic effect on the uterus, thereby increasing the risk of endometrial hyperplasia, endometrial polyp, and malignant mixed Mullerian tumor (MMMT). This case describes the pathogenesis and risk of MMMT due to long-term tamoxifen intake in hormone-responsive breast cancer.


Antioestrogenic effect; malignant mixed mullerian tumor; tamoxifen

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