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Asian J Transfus Sci. 2018 Jul-Dec;12(2):157-159. doi: 10.4103/ajts.AJTS_128_16.

Manual red cell exchange transfusion to avert sickle cell related complications.

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Department of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, Mumbai, Maharashtra, India.


Sickle cell-beta thalassemia is a double heterozygous state. Red cell exchange (RCE) transfusion reduces the concentration of sickle cells without increasing the hematocrit or whole-blood viscosity. It can be performed manually or by erythrocytapheresis. RCE transfusion is an effective tool for both acute and chronic complications of sickle cell disease. In patients unaffording erythrocytapheresis, even manual RCE can give favorable results. A 37-year-old male, a known case of sickle cell-beta+ thalassemia (βsβ+), presented with avascular necrosis of right femur and humeral head. He was posted for the right hip arthroplasty and shoulder hemiarthroplasty. Successful manual RCE transfusions were done. The hemoglobin S levels decreased postmanual RCE procedures, and the patient was operated successfully.


Complications; erythrocytapheresis; manual; red cell exchange; sickle cell disease; thalassemia

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