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Asian J Transfus Sci. 2018 Jul-Dec;12(2):123-126. doi: 10.4103/ajts.AJTS_119_17.

Intra- and inter-model reliability of Hemocue Hb 201+ and HemoCue Hb 301 devices.

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Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences, SRHU, Dehradun, Uttarakhand, India.
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.



The study intended to estimate the intra- and inter-model reliability and agreement between the HemoCue Models 201+ and 301 in a blood bank donor screening setting.


Venous blood samples from 115 blood donors were analyzed by two Hemocue 201+ instruments and two HemoCue 301 instruments. The Lin's concordance correlation coefficient (CCC) as well as the Bland-Altman limits of agreement was measured.


The 95% lower confidence interval (CI) of all the CCCs had a value >0.90. The CCC between instruments belonging to the same model was compared to instruments belonging to different models. The mean of HemoCue 301 was higher than HemoCue 201+ by 3.04 g/L with the 95% CI of the differences (i.e., the limits of agreement) between the two models ranging from -3.35 to 9.44 g/L. The bias between two instruments was lesser, and the limits of agreement were even narrower between instruments belonging to the same model.


The inter-instrument reliability and agreement are satisfactory in a blood bank setting.


Anemia; hemoglobin; method comparison; point-of-care testing; reliability

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