Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma

Cynthia J Koziol-White; Reynold A Panettieri Jr

doi:10.1016/j.ccm.2018.10.003

Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma

Clin Chest Med. 2019 Mar;40(1):51-57. doi: 10.1016/j.ccm.2018.10.003. Epub 2018 Dec 19.

Authors

Cynthia J Koziol-White¹, Reynold A Panettieri Jr²

Affiliations

¹ Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers Institute for Translational Medicine and Science, Rutgers University, State University of New Jersey, 89 French Street, Suite 4268, New Brunswick, NJ 08901, USA. Electronic address: cjk167@rbhs.rutgers.edu.
² Department of Medicine, Rutgers Institute for Translational Medicine and Science, Rutgers University, State University of New Jersey, 89 French Street, Room 4210, New Brunswick, NJ 08901, USA.

Abstract

Airway smooth muscle is the primary cell mediating bronchomotor tone. The milieu created in the asthmatic lung modulates airway smooth muscle contractility and relaxation. Experimental findings suggest intrinsic abnormalities in airway smooth muscle derived from patients with asthma in comparison with airway smooth muscle from those without asthma. These changes to excitation-contraction pathways may underlie airway hyperresponsiveness and increased airway resistance associated with asthma.

Keywords: Airway obstruction; Airway remodeling; Asthma; Bronchoconstriction; Bronchodilation.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Airway Resistance / immunology*
Asthma / immunology*
Bronchoconstriction / immunology*
Bronchodilator Agents / immunology*
Humans
Muscle, Smooth / metabolism*

Substances

Bronchodilator Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding