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Ann Biomed Eng. 2019 Jan 28. doi: 10.1007/s10439-019-02213-4. [Epub ahead of print]

Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage.

Author information

1
Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland. mohammadhossein.ebrahimi@uef.fi.
2
Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. mohammadhossein.ebrahimi@uef.fi.
3
Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.
4
Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
5
Kuopio University Hospital, Kuopio, Finland.

Abstract

Articular cartilage constituents (collagen, proteoglycans, fluid) are significantly altered during osteoarthritis (OA). A fibril-reinforced poroelastic (FRPE) material model can separate the contribution of each constituent on the mechanical response of cartilage. Yet, these properties and their OA related alterations are not known for human tibial cartilage. To answer this gap in the knowledge, we characterized the FRPE as well as elastic and viscoelastic properties of healthy and osteoarthritic human tibial cartilage. Tibial osteochondral explants (n = 27) harvested from 7 cadavers were mechanically tested in indentation followed by a quantification of elastic, viscoelastic and FRPE properties. Then they were histopathologically OARSI graded for the severity of OA. FRPE modeling revealed that non-fibrillar matrix modulus was higher in the healthy group compared to the early OA (p = 0.003) and advanced OA (p < 0.001) groups. The initial fibril network modulus was also higher in the healthy group compared to the early OA (p = 0.009) and advanced OA (p < 0.001) groups. The permeability correlated with the OARSI grade (p = 0.002, r = 0.56). For the first time, the FRPE properties were characterized for human tibial cartilage. This knowledge is crucial to improve the accuracy of computational knee joint models.

KEYWORDS:

Articular cartilage; Dynamic testing; Finite element analysis; OARSI grade; Osteoarthritis; Stress-relaxation

PMID:
30690688
DOI:
10.1007/s10439-019-02213-4

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