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Eur J Pharmacol. 2019 Apr 5;848:49-54. doi: 10.1016/j.ejphar.2019.01.034. Epub 2019 Jan 25.

Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats.

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Department of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Department of Neurosurgery, Ankang Central Hospital, Ankang, China.
HKBU Institute for Research and Continuing Education, Shenzhen, China; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Electronic address:
HKBU Institute for Research and Continuing Education, Shenzhen, China. Electronic address:


The aim of this study is to investigate the protective effect and underlying molecular mechanisms of isobavachalcone on Sephadex-induced lung injury in rats. The result showed isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. The ELISA assay exhibited isobavachalcone decreased TNF-α production in BALF and lung tissue. Western blotting analysis showed isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Furthermore, we also found isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression. Taken together, the present results suggested that isobavachalcone can attenuate Sephadex-induced lung injury that may be related to inhibition of NF-κB mediated by upregulation of A20 and activation of NRF2/HO-1 signaling pathway.


A20; Isobavachalcone; Lung injury; NF-κB; NRF2/HO-1

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