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Clin Infect Dis. 2019 Jan 28. doi: 10.1093/cid/ciy897. [Epub ahead of print]

Isolation of Nontuberculous Mycobacteria in Southeast Asian and African Human Immunodeficiency Virus-infected Children With Suspected Tuberculosis.

Author information

1
Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
2
Biochemistry, Hematology and Immunology Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam.
3
Medical Biology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
4
Microbiology Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam.
5
Service de Mycobactériologie, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur, Yaounde, Cameroon.
6
Centre Hospitalier Universitaire Souro Sanou, Bobo Dioulasso, Burkina Faso.
7
TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia.
8
University of Health Sciences, Phnom Penh, Cambodia.
9
UMI 233-TransVIHMI, Institut de Recherche pour le Développement (IRD), U1175, Université de Montpellier, France.
10
Service d'Epidémiologie et de Santé Publique, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur, Yaounde, Cameroon.
11
Service de Pédiatrie, Centre Hospitalier Universitaire Souro Sanou, Bobo Dioulasso, Burkina Faso.
12
Department of Clinical Sciences LUND, Section for Infection Medicine, Lund University, Sweden.
13
Service de Pneumologie et d'Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), France.
14
Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, France.
15
France (SG) Unité Mixte de Recherche (UMR) Maladies Infectieuses et Vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) IRD - Centre National de la Recherche Scientifique (CNRS), Université de Montpellier, IRD, délégation Occitanie, Montpellier, France (SG).
16
Unité d'Immunologie Hématologie Rhumatologie Pédiatrique, Hôpital Necker Enfants Malades, AP-HP, Paris, France.
17
Université de Bordeaux, Centre Institut national de la santé et de la recherche médicale U1219, Bordeaux Population Health, France.

Abstract

We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Nontuberculous mycobacteria were isolated in 46 children (10.8%); 45.7% of isolates were Mycobacterium avium complex. Southeast Asian origin, age 5-9 years, and severe immunodeficiency were independently associated with nontuberculous mycobacteria isolation.

PMID:
30689814
DOI:
10.1093/cid/ciy897

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