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Nanomedicine (Lond). 2019 Feb;14(4):375-385. doi: 10.2217/nnm-2018-0251. Epub 2019 Jan 28.

Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: in vitro and in vivo studies.

Author information

1
Laboratorio de Biomembranas - GBEyB (IMBICE, CCT-La Plata, CONICET), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, 1876 Bernal, Argentina.
2
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CCT-La Plata-CONICET, Universidad Nacional de La Plata, 1900 La Plata, Argentina.
3
Instituto de Nanosistemas (INS), Universidad Nacional de San Martin, 1650 San Martín, Argentina.
4
CONICET- Universidad de Buenos Aires, Instituto de Química Biológica Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina, 1428 Ciudad Autónoma de Buenos Aires, Argentina.

Abstract

AIM:

Amino functionalization is a first step modification aiming to achieve biomedical applications of silicon nanoparticles, for example, for photodynamic therapy or radiotherapy. Nevertheless, toxicity and low quantum yields due to the positive charge of amino groups emerge as a problem that could be solved with subsequent derivatizations.

MATERIALS & METHODS:

Folic and PEG-conjugated nanoparticles were obtained from amino-functionalized silicon nanoparticle (NH2SiNP). Cytotoxicity was determined on a tumor cell line at low and high concentrations. Four end points of in vivo toxicity were evaluated on zebrafish (Danio rerio).

RESULTS:

Folic acid functionalization reduced the cytotoxicity in comparison to amino and PEG-functionalized nanoparticles. In zebrafish, folic functionalization lowered toxicity in general while PEG increased it.

CONCLUSION:

Functionalization of NH2SiNP with folic acid reduced the toxic effects in vitro and in vivo. This could be useful for therapeutic applications. PEG functionalization did not lower the toxicity.

KEYWORDS:

folic acid; silicon nanoparticles; zebrafish

PMID:
30688554
DOI:
10.2217/nnm-2018-0251
[Indexed for MEDLINE]

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