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Cell. 2019 Feb 21;176(5):1128-1142.e18. doi: 10.1016/j.cell.2018.12.023. Epub 2019 Jan 24.

A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration.

Author information

1
Department of Biology, Stanford University, Stanford, CA 94305, USA.
2
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
3
Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
4
Department of Biology, Ball State University, Muncie, IN 47306, USA.
5
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
6
Departments of Neurology, Pathology and Cell Biology, and Pharmacology, Columbia University Irving Medical Center, New York, NY 10032, USA.
7
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: joswoo@stanford.edu.
8
Department of Biology, Stanford University, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kredhors@stanford.edu.

Abstract

Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to preserve tissue following vascular occlusion. Some patients with heart disease develop collateral coronary arteries, and this correlates with increased survival. However, it is not known how these collaterals develop or how to stimulate them. We demonstrate that neonatal mouse hearts use a novel mechanism to build collateral arteries in response to injury. Arterial endothelial cells (ECs) migrated away from arteries along existing capillaries and reassembled into collateral arteries, which we termed "artery reassembly". Artery ECs expressed CXCR4, and following injury, capillary ECs induced its ligand, CXCL12. CXCL12 or CXCR4 deletion impaired collateral artery formation and neonatal heart regeneration. Artery reassembly was nearly absent in adults but was induced by exogenous CXCL12. Thus, understanding neonatal regenerative mechanisms can identify pathways that restore these processes in adults and identify potentially translatable therapeutic strategies for ischemic heart disease.

KEYWORDS:

CXCL12; arterialization; arteriogenesis; collateral arteries; endothelial cells; heart regeneration; myocardial infarction

PMID:
30686582
DOI:
10.1016/j.cell.2018.12.023

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