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Ophthalmologica. 1988;197(4):179-84.

Clinical application of epiderm growth factor in patients with most severe eye burns.

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Abteilung Augenheikunde, Medizinische Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen.


20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium.

[Indexed for MEDLINE]

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