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Ann Pharm Fr. 2019 Jan 23. pii: S0003-4509(18)30186-X. doi: 10.1016/j.pharma.2018.12.002. [Epub ahead of print]

IPADAM "Pharmaceutical interventions on the issue of pharmaceutical records and self-medication" quanti survey in 482 French pharmacies.

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UFR Pharmacie - UCA, 28, place Henri-Dunant, 63001 Clermont-Ferrand, France. Electronic address:
UPU ACCePPT, Pharmacy UFR, the University of Clermont Auvergne, 63000 Clermont-Ferrand, France.
Pharmaceutical mathematics and physics laboratory, Faculty of pharmaceutical and biological sciences, University of Rennes 1, 35043 Rennes, France.
UMR 7213 CNRS, Pharmacy UFR, University of Strasbourg, 67401 Illkirch, France.
Inserm U 1219, Medecine UFR, University of Bordeaux, 33000 Bordeaux, France.
EA 2415, Faculty of Pharmacy, University of Montpellier, 34096 Montpellier, France.
Inserm U 1088 Unit, Pharmacy UFR, University of Picardy Jules Verne, 80000 Amiens, France.
Therapeutic and organic chemistry laboratory, Faculty of Pharmacy, University of Limoges, 87025 Limoges, France.
Department of Clinical Research and Innovation, CHU (University Hospital), 63000 Clermont-Ferrand, France.



This study aims to: (i) quantify the number of pharmaceutical interventions (PIs) linked to spontaneous requests for the two oral target molecules, ibuprofen and pseudoephedrine (ii) analyse the causes and proposed solutions (iii) quantify the number of registrations in the patient's pharmaceutical record and identify the various causes of non-registration.


The study was conducted over a 2 weeks' period in the months of February and April 2014 in 482 pharmacies affiliated to the training supervisor associations of 8 French Faculties of Pharmacy. Data regarding spontaneous requests for the target molecules was collected, with due respect to a patient care flow chart at the pharmacy, by incorporating the systematic proposal for registration of the medication in the patient's pharmaceutical record. Each PI was the subject of a notification made with reference to a standardized grid.


A total of 12,160 dispensations were made over the two weeks of the study. Overall 815 of them gave rise to an PI (6.7%), justified in almost half of the cases by a contraindication. The alternative proposed by the dispensing pharmacist was accepted in more than 9 out of 10 cases. In half of the cases, the dispensing pharmacist had access to the patient's French healthcare card; more than 2/3 of the dispensations thus led to the registration of the medication in the patient's pharmaceutical record.


The pairing of the two tools, these being the notification grid and the pharmaceutical record, aims to maximize dispensation security while patients are being guided in their approach to self-medication.


Automédication; Ibuprofen; Ibuprofène; Intervention pharmaceutique; Pharmaceutical intervention; Pseudoephedrine; Pseudoéphédrine; Quantitative study; Self-medication; Étude quantitative

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