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Nutr Res. 2019 Jan;61:31-40. doi: 10.1016/j.nutres.2018.10.004. Epub 2018 Oct 13.

Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma.

Author information

1
La Trobe University, School of Allied Health, Department of Rehabilitation, Nutrition & Sport, Melbourne, Australia. Electronic address: M.Papamichael@latrobe.edu.au.
2
National & Kapodistrian University of Athens, Athens, Greece. Electronic address: xkatsardis@med.uoa.gr.
3
La Trobe University, School of Psychology & Public Health, Department of Public Health, Melbourne, Australia. Electronic address: b.erbas@latrobe.edu.au.
4
La Trobe University, School of Allied Health, Department of Rehabilitation, Nutrition & Sport, Melbourne, Australia. Electronic address: C.Itsiopoulos@latrobe.edu.au.
5
European Institute of Nutritional Medicine, Rome, Italy. Electronic address: dtsoukalas@einum.org.

Abstract

Childhood asthma prevalence continues to rise despite advancements in prevention and medical management strategies. The purpose of this study was to investigate correlations between urinary organic acids and pulmonary diagnostic tests, asthma control in Greek asthmatic children. We hypothesized that urinary organic acids are positively associated with poor pulmonary function in children with asthma. Seventy-two children, 5 to 12 years old with asthma were recruited from a pediatric asthma clinic in Athens, Greece. Pulmonary function was assessed using spirometry and exhaled nitric oxide analysis. Asthma control was measured qualitatively using the Asthma Control Questionnaire. Targeted metabolomic analysis of 34 urinary organic acids in children was conducted by gas chromatography-mass spectrometry. A statistically significant difference between girls and boys was found for asthma control score (P = .02), lactic acid (P = .03), but not for any other organic acids (P > .05). Statistically significant correlations were found between lactic acid and Forced Expiratory Volume in 1 second (FEV1) (P = .02), Forced Vital Capacity (FVC) (P = .03); 4- hydroxyphenylacetic acid and FEV1 (P = .01), FVC (P = .01); 5-hydroxyindoleacetic acid and FEV1/FVC (P = .03), eNO (P = .05); glycolic acid with Peak Expiratory Flow (PEF) (P = .03); and malic acid with asthma control (P = .02). In conclusion, metabolomics was used to determine correlations between urinary organic acids and conventional pulmonary diagnostic tests in Greek asthmatic children. Metabolomics could be a promising approach for asthma research and in detection of novel biomarkers for asthma monitoring and therapeutic targets for childhood asthma. This study contributes towards a better understanding of the biochemical pathways involved in asthma.

KEYWORDS:

Asthma; Children; Gas-chromatography–mass spectroscopy; Metabolic profile; Metabolomics; Urinary organic acids

PMID:
30683437
DOI:
10.1016/j.nutres.2018.10.004
[Indexed for MEDLINE]

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