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Cell. 2019 Jan 24;176(3):416-418. doi: 10.1016/j.cell.2018.12.025.

Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues.

Author information

1
Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: thomas.korn@tum.de.

Abstract

By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.

PMID:
30682369
DOI:
10.1016/j.cell.2018.12.025
[Indexed for MEDLINE]

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