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Medicine (Baltimore). 2019 Jan;98(4):e14275. doi: 10.1097/MD.0000000000014275.

Efficacy and safety of herbal medicine (Bailemian capsule) for treating insomnia: Protocol for a systematic review and meta-analysis.

Author information

Department of Neurology, Guizhou Provincial People's Hospital, Guiyang, Guizhou.
College of Mongolian Medicine, Inner Mongilia Medical University, Hohhot, Inner Mongolia.
Human Anatomy and Tissue Embryology, Weifang Medical University, Weicheng, Weifang, Shandong.
Department of Pharmacy, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China.



Insomnia has become a universal subhealth disease, affecting more and more modern people's health and quality of life. At present, western medicine is only symptomatic treatment for insomnia. Bailemian Capsule (BLMC) is a proprietary Chinese medicine for treating insomnia. It has been widely used in China, but lacks evidence for evidence-based medicine. At the same time, the clinical efficacy and safety of BLMC are controversial. Therefore, the effectiveness and safety of BLMC in the treatment of insomnia are studied and systematically evaluated in this study. It provides reliable theoretical support for the treatment of insomnia with Traditional Chinese Medicine and the combination of traditional Chinese and Western medicine.


The information was retrieved from electronic databases, Cochrane, PubMed, EMBASE, SinoMed, China National Knowledge Infrastructure, VIP Data, and WangFang Data. Randomized controlled trials on the BLMC in the treatment of insomnia were conducted. There was no limitation on the literature language. RevMan 5.3 software and STATA 12.0 software were used to perform the meta-analysis.


This review will be to assess the efficacy and safety of BLMC for insomnia.


Our systematic evaluation will provide evidence for the clinical efficacy and safety of BLMC in the treatment of insomnia, and will be published in the form of academic papers in the future to provide new ideas for clinicians in the treatment of insomnia.

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