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Pain Manag. 2019 Mar 1;9(2):205-216. doi: 10.2217/pmt-2018-0052. Epub 2019 Jan 25.

Nonopioid versus opioid agents for chronic neuropathic pain, rheumatoid arthritis pain, cancer pain and low back pain.

Author information

1
Department of Pain Management, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
2
Department of Anesthesiology, NewYork-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, 10065, USA.
3
Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL, 60612 USA.
4
Department of Anesthesia & Critical Care, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Abstract

Chronic pain continues to be a major health issue throughout the world and a huge economic burden for nations around the world. While the use of opioids does have risks, they are still widely used by clinicians as a treatment option for various chronic pain conditions. This review explores and compares the efficacy and safety of opioid and nonopioid agents for the following commonly encountered chronic pain conditions: neuropathic pain, rheumatoid arthritis joint pain, cancer pain and low back pain. Our findings demonstrate that while there are several nonopioid pharmacologic options that are clinically effective, opioids maintain a role in the treatment of certain chronic pain conditions and should continue to have an important place in the armamentarium of clinicians.

KEYWORDS:

cancer pain; inflammatory pain; low back pain; neuropathic pain; opioids; rheumatologic pain

PMID:
30681031
DOI:
10.2217/pmt-2018-0052
[Indexed for MEDLINE]

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