Send to

Choose Destination
Pain Manag. 2019 Mar 1;9(2):205-216. doi: 10.2217/pmt-2018-0052. Epub 2019 Jan 25.

Nonopioid versus opioid agents for chronic neuropathic pain, rheumatoid arthritis pain, cancer pain and low back pain.

Author information

Department of Pain Management, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Department of Anesthesiology, NewYork-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, 10065, USA.
Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL, 60612 USA.
Department of Anesthesia & Critical Care, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.


Chronic pain continues to be a major health issue throughout the world and a huge economic burden for nations around the world. While the use of opioids does have risks, they are still widely used by clinicians as a treatment option for various chronic pain conditions. This review explores and compares the efficacy and safety of opioid and nonopioid agents for the following commonly encountered chronic pain conditions: neuropathic pain, rheumatoid arthritis joint pain, cancer pain and low back pain. Our findings demonstrate that while there are several nonopioid pharmacologic options that are clinically effective, opioids maintain a role in the treatment of certain chronic pain conditions and should continue to have an important place in the armamentarium of clinicians.


cancer pain; inflammatory pain; low back pain; neuropathic pain; opioids; rheumatologic pain

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center