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Pain Manag. 2019 Mar 1;9(2):191-203. doi: 10.2217/pmt-2018-0051. Epub 2019 Jan 25.

Perspectives on cannabis as a substitute for opioid analgesics.

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Department of Pharmaceutical Sciences, Regis University School of Pharmacy, 3333 Regis Blvd. H-28, Denver, CO 80221, USA.


With the opioid epidemic reaching new heights in the USA, it has become critical to find suitable alternatives to opioids. Cannabis, an antinociceptive, is a strong contender to help patients reduce their opioid usage. A growing literature has been examining the complex effects cannabis has on pain relief and on opioid usage; whether it is a substitute for opioids or increases their use. This review explores the studies that compare cannabis-opioid interactions and presents some challenges of cannabis research and usage. The practical clinical pharmacology of cannabis as an analgesic, including the route of administration, safety and pharmacokinetics, are discussed to address the concerns, as well as possible solutions, of cannabis as a pain reliever.


analgesia; marijuana; mu-opioid receptor agonists; opioid-sparing effect; synthetic CB2 agonist

[Indexed for MEDLINE]

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