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Br J Clin Pharmacol. 2019 May;85(5):908-913. doi: 10.1111/bcp.13871. Epub 2019 Feb 28.

Treatment of exudative age-related macular degeneration with aflibercept combined with pranoprofen eye drops or nutraceutical support with omega-3: A randomized trial.

Author information

1
Eye Clinic, Department of Neurological and Vision Sciences, University of Brescia, Italy.
2
Eye Clinic, Department of Health Sciences, University of Molise, Campobasso, Italy.

Abstract

AIMS:

The aim of this study was to determine whether a combination of intravitreal aflibercept (IVA) and pranoprofen eyedrops or nutraceutical support provides additional benefit over IVA monotherapy for the treatment of choroidal neovascularization (CNV) in age-related macular degeneration.

METHODS:

This was a prospective, randomized, pilot study in 60 patients with treatment-naïve CNV. Patients were randomized 1:1:1 into three groups: aflibercept monotherapy (AM), aflibercept plus pranoprofen (AP) or aflibercept plus nutraceutical (AN) tablets containing multivitamin antioxidant and mineral supplementation plus omega-3.

RESULTS:

At 12 months, all groups showed significant improvement in both best-corrected visual acuity (BCVA) and central retinal thickness (CRT). The mean BCVA change from baseline to 12 months was -0.26 ± 0.06 LogMAR, -0.30 ± 0.06 LogMAR and -0.24 ± 0.04 LogMAR in the AM, AP and AN groups, respectively. The mean CRT change from baseline to 12 months was -76.9 ± 10.9 μm, -129 ± 19.9 μm and -105 ± 11.6 μm in the AM, AP and AN groups, respectively. The AN group required one less IVA injection than the AM group.

CONCLUSIONS:

Compared with AM, both combination groups acted synergistically, although no significant benefits in BCVA were found over AM. Nutraceutical support with omega-3 leads to a reduced need for IVA.

KEYWORDS:

aflibercept; age-related macular degeneration; multivitamin antioxidant; omega-3; pranoprofen

PMID:
30680768
PMCID:
PMC6475693
[Available on 2020-05-01]
DOI:
10.1111/bcp.13871

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