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Aging Clin Exp Res. 2019 Dec;31(12):1817-1825. doi: 10.1007/s40520-019-01125-6. Epub 2019 Jan 24.

Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study.

Author information

1
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Building 57, 66421, Homburg, Saar, Germany.
2
Fachhochschule des Mittelstands, University of Applied Sciences, 50674, Cologne, Germany.
3
Institute of Alternative and Sustainable Nutrition, 35444, Biebertal, Giessen, Germany.
4
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Building 57, 66421, Homburg, Saar, Germany. rima.obeid@uks.eu.
5
Aarhus Institute of Advanced Studies, Aarhus University, 8000, Aarhus C, Denmark. rima.obeid@uks.eu.

Abstract

BACKGROUND:

Elderly people are at risk for vitamin B12 deficiency.

AIMS:

We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects.

METHODS:

We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months.

RESULTS:

92 subjects met the inclusion criteria, completed the 3 months study, and were included in the data analysis. After the intervention, concentrations of vitamin B12 were higher [mean (SD) = 368 (123) vs. 295 (123) pmol/L; p = 0.005] and holoTC tended to be higher [112 (48) vs. 91 (68) pmol/L; p = 0.088] in the vitamin B12 group compared with the placebo group. The changes of serum vitamin B12 [54 (74) vs. 3 (60) pmol/L, p < 0.001], holoTC [21 (34) vs. 2 (32) pmol/L, p = 0.007], and tHcy [- 0.9 (2.3) vs. 0.3 (1.9) µmol/L, p = 0.010] were significantly different between the intervention groups. Mean percentage increase of serum vitamin B12 (+ 23% corresponds to + 54 pmol/L) in the vitamin B12 toothpaste group suggests that the intervention had provided an additional daily intake of approximately + 7 µg oral B12. Common diseases and drugs did not predict the change of blood markers in the vitamin group. No side effects were observed.

CONCLUSIONS:

The toothpaste enriched with 100 µg cyanocobalamin/g has increased vitamin B12 status and can thus be used for preventing vitamin B12 depletion in elderly people. The trial was registered at ClinicalTrials.gov: NCT02679833.

KEYWORDS:

Elderly; Holotranscobalamin; Supplementation; Vitamin B12 deficiency

PMID:
30680547
DOI:
10.1007/s40520-019-01125-6

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