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Food Sci Nutr. 2018 Dec 1;7(1):183-194. doi: 10.1002/fsn3.851. eCollection 2019 Jan.

Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high-fat diet.

Author information

1
Department of Animal Nutrition Faculty of Veterinary Science Firat University Elazig Turkey.
2
Department of Animal Nutrition Faculty of Veterinary Science Erciyes University Kayseri Turkey.
3
Division of Biology Faculty of Science Firat University Elazig Turkey.
4
Scientific and Regulatory Affairs Nutrition 21 Inc. Purchase NY USA.

Abstract

Scope:

To investigate the effects of chromium histidinate (CrHis) and chromium picolinate (CrPic) complex along with biotin to a high-fat diet (HFD) fed to rats on the insulin sensitivity and the anti-obesity properties.

Methods:

Forty-two Sprague-Dawley male rats were divided into six groups. The rats were fed either (a): a standard diet (Control) or (b): a HFD or (c): a HFD with biotin (HFD+B) or (d): a combination of HFD and biotin along with CrPic (HFD + B + CrPic) or (e): a combination of HFD and biotin along with CrHis (HFD + B + CrHis) or (f): a combination of HFD and biotin along with CrHis and CrPic (HFD + B + CrHis + CrPic).

Results:

Adding biotin with chromium to HFD improved the glucose, insulin, HOMA-IR, leptin, lipid profile, with HFD+B+CrHis treatment being the most effective (p = 0.0001). Serum, liver, and brain tissue Cr concentrations increased upon Cr supplementations (= 0.0001). Supplementing CrHis along with biotin to a HFD (HFD + B + CrHis) provided the greatest levels of GLUT-1, GLUT-3, PPAR-γ, and IRS-1, but the lowest level of NF-κB in the brain and liver tissues.

Conclusion:

Biotin supplementation with chromium complexes, CrHis in particular, to a HFD pose to be a potential therapeutic feature for the treatment of insulin resistance.

KEYWORDS:

GLUTs; biotin; chromium histidinate; chromium picolinate; high‐fat diet

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