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Egypt J Neurol Psychiatr Neurosurg. 2019;55(1):1. doi: 10.1186/s41983-018-0047-6. Epub 2019 Jan 5.

Use of low-power He-Ne laser therapy to accelerate regeneration processes of injured sciatic nerve in rabbit.

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1Experimental Therapy Department, Iraqi Center for Cancer and Medical Genetic Research, Mustansiriyah University, Baghdad, 1001 Iraq.
2Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.



Photostimulation using low-power laser had been used for nervous repair with interesting results. This study aimed to evaluate the influence of 20 mW low-power He-Ne laser on the regeneration of a peripheral sciatic nerve after trauma using the Albino rabbit as an animal model for experimental treatment.


Six adult male rabbits were randomly assigned into two equal groups (control- and laser-treated). General anesthesia was administered intramuscularly, and exploration of the sciatic nerve was done in the lateral aspect of the legs. Complete longitudinal and reverse sections of the nerve were performed, which was followed by crushing of the neural sheath. Treatment was carried out directly after the trauma. Irradiation doses of low-level laser therapy (LLLT-31.5 J/cm2 ) with once a day application for 10 consecutive days and observed for 30 days. The animals were followed up for an extra 2 weeks. Two important factors were examined histopathology and functionality of the nerve.


Compared to the control group, significant variations in regeneration were observed, including thicker nerve fibers, and more regular myelin layers in the treated group.


The results of the present study suggest that laser therapy may be a viable approach for nerve regeneration and repair.


Nerve healing; Nerve injuries; Peripheral nerve; Photostimulation; Wallerian degeneration

Conflict of interest statement

Manuscripts reporting studies involving human participants, human data or human tissue must: Not applicable. Studies involving animals must include a statement on ethics approval. The experimental procedures followed the guidelines for the ethical treatment of experimental animals and were approved by Mustansiriyah University, Iraqi Center for Cancer and Medical Genetic Research, Animal Care and Use Ethics Committee. The date of ethical approval is 7/30/2010, and reference number was 5.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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