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Sci Rep. 2019 Jan 24;9(1):593. doi: 10.1038/s41598-018-37561-z.

Hippocampal gamma predicts associative memory performance as measured by acute and chronic intracranial EEG.

Author information

1
New York University Comprehensive Epilepsy Center, 223 East 34th Street, New York, NY, 10016, USA. simon.henin@nyumc.org.
2
Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY, 10016, USA. simon.henin@nyumc.org.
3
New York University Comprehensive Epilepsy Center, 223 East 34th Street, New York, NY, 10016, USA.
4
Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY, 10016, USA.
5
NeuroPace, Inc., 455 N. Bernardo Avenue, Mountain View, CA, 94043, USA.
6
Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Gruneburgweg 14, 60322, Frankfurt am Main, Germany.
7
Department of Psychology, New York University, 6 Washington Place, New York, NY, 10003, USA.
8
Department of Neurosurgery, New York University School of Medicine, 530 1st Avenue, Suite 7W, New York, NY, 10016, USA.
9
Columbia University, Department of Psychology, 1190 Amsterdam Ave #406, New York, NY, 10027, USA.
10
New York University Comprehensive Epilepsy Center, 223 East 34th Street, New York, NY, 10016, USA. anli.liu@nyumc.org.
11
Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY, 10016, USA. anli.liu@nyumc.org.

Abstract

Direct recordings from the human brain have historically involved epilepsy patients undergoing invasive electroencephalography (iEEG) for surgery. However, these measurements are temporally limited and affected by clinical variables. The RNS System (NeuroPace, Inc.) is a chronic, closed-loop electrographic seizure detection and stimulation system. When adapted by investigators for research, it facilitates cognitive testing in a controlled ambulatory setting, with measurements collected over months to years. We utilized an associative learning paradigm in 5 patients with traditional iEEG and 3 patients with chronic iEEG, and found increased hippocampal gamma (60-100 Hz) sustained at 1.3-1.5 seconds during encoding in successful versus failed trials in surgical patients, with similar results in our RNS System patients (1.4-1.6 seconds). Our findings replicate other studies demonstrating that sustained hippocampal gamma supports encoding. Importantly, we have validated the RNS System to make sensitive measurements of hippocampal dynamics during cognitive tasks in a chronic ambulatory research setting.

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