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G3 (Bethesda). 2019 Mar 7;9(3):807-816. doi: 10.1534/g3.118.200852.

Tissue-Specific Transcriptome Analysis Reveals Candidate Genes for Terpenoid and Phenylpropanoid Metabolism in the Medicinal Plant Ferula assafoetida.

Author information

1
Department of Plant Biology, University of California, Davis, CA 95616.
2
Department of Agronomy and Plant Breeding, Agricultural and Natural Resources College, University of Tehran, Iran, 77871-31587.
3
Department of Agronomy and Plant Breeding, Agricultural and Natural Resources College, University of Tehran, Iran, 77871-31587 jnmaloof@ucdavis.edu mnaghavi@ut.ac.ir.
4
West Coast Metabolomics Center, University of California, Davis, CA 95616.
5
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, MS 38677.
6
Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi-Arabia.
7
Department of Plant Biology, University of California, Davis, CA 95616 jnmaloof@ucdavis.edu mnaghavi@ut.ac.ir.

Abstract

Ferula assafoetida is a medicinal plant of the Apiaceae family that has traditionally been used for its therapeutic value. Particularly, terpenoid and phenylpropanoid metabolites, major components of the root-derived oleo-gum-resin, exhibit anti-inflammatory and cytotoxic activities, thus offering a resource for potential therapeutic lead compounds. However, genes and enzymes for terpenoid and coumarin-type phenylpropanoid metabolism have thus far remained uncharacterized in F. assafoetida Comparative de novo transcriptome analysis of roots, leaves, stems, and flowers was combined with computational annotation to identify candidate genes with probable roles in terpenoid and coumarin biosynthesis. Gene network analysis showed a high abundance of predicted terpenoid- and phenylpropanoid-metabolic pathway genes in flowers. These findings offer a deeper insight into natural product biosynthesis in F. assafoetida and provide genomic resources for exploiting the medicinal potential of this rare plant.

KEYWORDS:

RNAseq; coumarin-type phenylpropanoids; medicinal plant; terpenoid

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