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AJNR Am J Neuroradiol. 2019 Mar;40(3):460-463. doi: 10.3174/ajnr.A5933. Epub 2019 Jan 24.

Quantitative Susceptibility Mapping to Assess Cerebral Vascular Compliance.

Author information

1
From the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria christoph.birkl@medunigraz.at.
2
University of British Columbia MRI Research Centre (C.B.), University of British Columbia, Vancouver, British Columbia, Canada.
3
From the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria.
4
Translational Neuroradiology Unit (P.S.), Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

Abstract

This study explored whether autoregulatory shifts in cerebral blood volume induce susceptibility changes large enough to be depicted by quantitative susceptibility mapping. Eight healthy subjects underwent fast quantitative susceptibility mapping at 3T while lying down to slowly decrease mean arterial pressure. A linear relationship between mean arterial pressure and susceptibility was observed in cortical and subcortical structures, likely representing vessels involved in autoregulation. The slope of this relationship is assumed to indicate the extent of cerebral vascular compliance.

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