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Cancer Res. 2019 Feb 1;79(3):423-436. doi: 10.1158/0008-5472.CAN-18-1805. Epub 2019 Jan 24.

A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis.

Author information

1
Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
2
Department of Internal Medicine III, Hematology and Medical Oncology, University Hospital Regensburg, Regensburg, Germany.
3
Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. netaerez@tauex.tau.ac.il.

Abstract

Brain metastases are more common than primary CNS tumors and confer grave prognosis on patients, as existing treatments have very limited efficacy. The tumor microenvironment has a central role in facilitating tumorigenesis and metastasis. In recent years, there has been much progress in our understanding of the functional role of the brain metastatic microenvironment. In this review, we discuss the latest advances in brain metastasis research, with special emphasis on the role of the brain microenvironment and neuroinflammation, integrating insights from comparable findings in neuropathologies and primary CNS tumors. In addition, we overview findings on the formation of a hospitable metastatic niche and point out the major gaps in knowledge toward developing new therapeutics that will cotarget the stromal compartment in an effort to improve the treatment and prevention of brain metastases.

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