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Curr Med Chem. 2019 Jan 24. doi: 10.2174/0929867326666190124124350. [Epub ahead of print]

Synthesis, Biological Activity and Medicinal Applications of Ruthenium Complexes Containing Carbohydrate Ligands.

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1
Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa. Portugal.

Abstract

The search for new metal-efficient drugs has attracted considerable attention of the scientific community. Among them, ruthenium complexes have emerged as an excellent alternative of platinum complexes. This review presents a thorough and timely coverage of the synthesis, biological activity and medicinal applications of ruthenium complexes bearing carbohydrate ligands, allowing a large community of readers, in particularly the community that works in organic, inorganic, bioorganometallic and medicinal chemistry, ready access to the most relevant examples.

KEYWORDS:

Ruthenium; arene complexes; carbohydrates; cyclopentadienyl complexes; nucleolipidic complexes; polypyridyl complexes; tricarbonyl complexes

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