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Curr Med Chem. 2019 Jan 24. doi: 10.2174/0929867326666190124123208. [Epub ahead of print]

Benzimidazole-derived compounds designed for different targets of Alzheimer's disease.

Author information

1
Eastern Mediterranean University, Faculty of Pharmacy, Division of Pharmaceutical Chemistry, Famagusta, TRNC, via Mersin 10 . Turkey.
2
Eastern Mediterranean University, Faculty of Pharmacy, Division of Pharmaceutical Chemistry, Famagusta, TRNC, via Mersin 10. Turkey.
3
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler, Ankara. Turkey.

Abstract

Benzimidazole scaffold has been efficiently used for the design of various pharmacologically active molecules. Indeed, there are various drugs, available today, employed for the treatment of different diseases. Although, there is no benzimidazole moiety containing drug available today for the treatment of Alzheimer's Disease (AD), there have been many benzimidazole derivative compounds designed and synthesized to act on some of the validated and non-validated targets of AD. This paper has aimed to review the literature to describe these benzimidazole containing molecules designed for the treatment of AD.

KEYWORDS:

Alzheimer’s Disease; Benzimidazoles; various targets.

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