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Sci Total Environ. 2019 Mar 20;657:863-870. doi: 10.1016/j.scitotenv.2018.11.453. Epub 2018 Dec 3.

Decreased plasma levels of perfluoroalkylated substances one year after bariatric surgery.

Author information

1
Department of Surgery, Innlandet Hospital Trust, Gjøvik, Norway; Department of Food Safety and Infection Biology, Norwegian University of Life Sciences (NMBU), Oslo, Norway. Electronic address: aina.jansen@sykehuset-innlandet.no.
2
Department of Food Safety and Infection Biology, Norwegian University of Life Sciences (NMBU), Oslo, Norway.
3
Department of Food Safety and Infection Biology, Norwegian University of Life Sciences (NMBU), Oslo, Norway; Department of Biology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
4
Oslo Centre for Biostatistics and Epidemiology, Section for Treatment Research, Department for Research and Education, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
5
Centre for Epidemiology and Biostatistics, Norwegian University of Life Sciences (NMBU), Oslo, Norway.
6
Innlandet Hospital Trust, Research Department, Brumunddal, Norway; Faculty of Health and Social Sciences, Inland Norway University of Applied Sciences, Elverum, Norway.

Abstract

Per- and polyfluoroalkylated substances (PFASs) are classified as persistent organic pollutants (POPs), and known to be protein bound. The aim of the present study was to determine the levels of 17 different PFASs before and one year after bariatric surgery, and to assess whether weight loss and changed serum protein concentrations could be influencing factors. Plasma samples from 63 patients were analyzed for nine perfluoroalkyl carboxylic acids (PFCAs), three perfluoroalkane sulfonic acids (PFSAs), and five perfluoroalkyl sulfonamide based substances (PASF) before and after surgery. Protein determination was performed in the corresponding serum samples. Mean weight loss one year after surgery was 32.1 kg. The plasma levels of all PFASs decreased with 4-34% compared to preoperative values, and included perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), and perfluorobutane sulfonate (PFBS), which have been identified with increasing levels in the general population during recent years. Serum protein concentrations also decreased with 7-8%. Although protein levels were positively correlated with PFOA, PFBS, PFHxS and PFOS, regression analysis revealed that neither weight loss nor reductions in concentrations of serum protein could explain the decreased PFAS levels. The type of surgical procedure did not influence the changes of PFAS levels between the two sample points. A reduced food intake and alterations in absorptions of nutrients after bariatric surgery may have influenced the observed decreasing plasma levels of PFASs.

KEYWORDS:

Albumin; Bariatric surgery; Obesity; Perfluoroalkylated substances; Total protein; Weight loss

PMID:
30677951
DOI:
10.1016/j.scitotenv.2018.11.453
[Indexed for MEDLINE]

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