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BJOG. 2019 Apr;126(5):663-673. doi: 10.1111/1471-0528.15593. Epub 2019 Jan 24.

Dietary patterns and the risk of pregnancy-associated hypertension in the Danish National Birth Cohort: a prospective longitudinal study.

Author information

1
Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK.
2
Department of Primary Care and Public Health, Imperial College, London, UK.
3
Department of Epidemiology Research, Centre for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark.
4
Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
5
Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
6
Danish Paediatric Asthma Centre, Gentofte Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
7
Department of Nutrition, Harvard Chan School of Public Health, Boston, MA, USA.
8
Danish Diabetes Academy, Odense, Denmark.

Abstract

OBJECTIVE:

To examine the association between mid-pregnancy dietary patterns and pregnancy-associated hypertension (PAH).

DESIGN:

A prospective longitudinal cohort study.

SETTING:

Denmark.

POPULATION:

About 55 139 Danish women with single enrolments and recorded food frequency questionnaire dates with complete information on dietary intake.

METHODS:

Women were eligible if they could speak Danish and were planning to carry to term. Diet was assessed using a validated semi-quantitative 360-item food frequency questionnaire and dietary patterns were derived using factor analysis.

MAIN OUTCOME MEASURES:

Gestational hypertension (GH) and pre-eclampsia (PE).

RESULTS:

Disease prevalence was 14% for GH (5491/39 362); 2% for PE (1168/54 778), and 0.4% for severe PE (234/55 086). Seven dietary patterns were characterised in the population, of which two were associated with PAH. The Seafood diet characterised by high consumption of fish and vegetables was inversely associated with the odds of developing GH [odds ratio (OR) 0.86; 95% CI 0.77-0.95)] and PE (OR 0.79; 95% CI 0.65-0.97). The Western diet characterised by high consumption of potatoes (including French fries), mixed meat, margarine and white bread increased the odds of developing GH (OR 1.18; 95% CI 1.05-1.33) and PE (OR 1.40; 95% CI 1.11-1.76). No association was seen with severe PE.

CONCLUSIONS:

We found protective associations of Seafood diet and harmful associations of Western diet with PAH. Dietary interventions encouraging the reduction of Western diet may contribute to a decrease of PAH.

TWEETABLE ABSTRACT:

Western diet increases (Seafood diet decreases) the likelihood of developing pre-eclampsia among Danish pregnant women.

KEYWORDS:

Dietary patterns; Western diet; gestational hypertension; pre-eclampsia; pregnancy-associated hypertension

PMID:
30675768
DOI:
10.1111/1471-0528.15593
[Indexed for MEDLINE]

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