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Cell Biosci. 2019 Jan 17;9:11. doi: 10.1186/s13578-019-0273-3. eCollection 2019.

Long non-coding RNA ANRIL-mediated inflammation response is involved in protective effect of rhein in uric acid nephropathy rats.

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1Department of Traditional Chinese Medicine, Renmin Hospital of Wuhan University, No. 99 Zhangzhidong Road, Wuhan, 430060 China.
2Department of Acupuncture and Moxibustion, Renmin Hospital of Wuhan University, Wuhan, 430060 China.



The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.


Rat models of UAN were induced by adenine and potassium oxonate. Enzyme-linked immunosorbent assay (ELISA) was performed to assess inflammation factor in serum and supernatant. ANRIL mRNA level was detected using real-time reverse transcription PCR (qRT-PCR). Immunostaining was used to observe pathological changes of renal tissues in rats.


ANRIL and inflammatory factor levels were highly expressed in patient with UAN. Furthermore, rhein showed an observable effect on anti-inflammatory and renal protection in UAN rats, rhein inhibited expressions of ANRIL in vivo or in vitro. Besides, ANRIL-mediated inflammatory response attenuated protective effect of rhein.


ANRIL-mediated inflammatory response attenuated the protective effect of rhein in UAN rats. This study showed an understanding of the role and mechanism of ANRIL in UAN, which provides a new target and therapy for the prevention and treatment of UAN.


Hyperuricemia; Inflammatory response; Long non-coding RNA ANRIL; Rhein; UAN

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