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J Atheroscler Thromb. 2019 Jan 23. doi: 10.5551/jat.47167. [Epub ahead of print]

Association of Plasma Pentraxin-3 Level with Lipid Levels and Cardiovascular Risk Factors in People with No History of Lipid-Lowering Medication: the Dong-gu Study.

Author information

1
Department of Preventive Medicine, Chonnam National University Medical School.
2
Department of Nursing, Nambu University.
3
Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine.
4
Department of Preventive Medicine, Chosun University Medical School.
5
Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital.

Abstract

AIM:

To elucidate the role of pentraxin-3 (PTX3) in atherosclerosis, we evaluated lipid and cardiovascular risk profiles according to the plasma PTX3 levels in subjects from the general population.

METHODS:

A sub-cohort of 2,000 subjects was randomly sampled from a Korean community-based cohort study. After excluding those with a medication history for dyslipidemia, 1,747 subjects (902 men and 845 women) were included in the final analyses. Linear and logistic regressions with adjustment for appropriate variables were performed.

RESULTS:

The PTX3 level was positively associated with the high-density lipoprotein cholesterol (HDL-C) level and negatively associated with the log-transformed triglyceride (TG) level, total cholesterol/HDL-C ratio, and low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (p<0.05). Subjects with the highest PTX3 levels (≥ 1.17 ng/dl) exhibited a lower risk of metabolic syndrome (odds ratio [OR] 0.73, 95% confidence interval [CI] 0.57-0.94), overweight/obesity (OR 0.65, 95% CI 0.50-0.83), increased TG level (OR 0.66, 95% CI 0.51-0.86), and increased HDL-C level (OR 0.67, 95% CI 0.51-0.88) compared to those with the lowest PTX3 level (<0.7 ng/dl).

CONCLUSION:

The circulating PTX3 level was inversely associated with metabolic syndrome, overweight/obesity, and parameters of dyslipidemia, suggesting a cardioprotective role of PTX3 in atherosclerosis.

KEYWORDS:

Atherosclerosis; Cardiovascular risk factor; Lipid; Pentraxin 3

PMID:
30674758
DOI:
10.5551/jat.47167
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